AF710B yog dab tsi? Phau Ntawv Qhia Txog Nws Cov Khoom thiab Daim Ntawv Thov

AF710B yog dab tsi?

AF710B (tseem hu ua ANAVEX 3-71) yog cov tshuaj molecule me me uas feem ntau ua rauM1 muscarinic receptorsthiabsigma-1 receptors. Raws li ib qho kev xaiv allosteric agonist, AF710B tuaj yeem koom nrog cov txheej txheem lom neeg muaj feem cuam tshuam los ntawm kev tswj hwm cov haujlwm tshwj xeeb.

M1 muscarinic receptor yog ib feem ntawm cholinergic system thiab muaj feem xyuam nrog cov txheej txheem neuronal signaling. Lub sigma-1 receptor yog ib qho receptor intracellular uas cuam tshuam nrog kev sib txuas lus ntawm tes, kev tswj hwm kev ua haujlwm ntawm lub hlwb, thiab kev ntxhov siab ntawm tes- cov txheej txheem cuam tshuam. Los ntawm kev ua ntawm ob hom receptors ib txhij, AF710B tuaj yeem siv los tshawb txog cov txheej txheem kev txawj ntse, kev ua haujlwm synaptic, thiab txoj hauv kev molecular koom nrog hauv kev tswj hwm lub paj hlwb.

Cov khoom tseem ceeb ntawm AF710B

Ib qho ntawm cov yam ntxwv tseem ceeb ntawm AF710B yog nws cov haujlwm receptor dual. Tsis zoo li cov tebchaw uas lub hom phiaj tsuas yog ib hom receptor, AF710B tuaj yeem ua rau ob qho tib si M1 muscarinic receptors thiab sigma-1 receptors, tso cai rau nws siv rau kev kawm kev sib cuam tshuam ntawm cov kev taw qhia sib txawv.

AF710B yog ib qho allosteric modulator compound, thiab nws cov txheej txheem sib txawv ntawm cov tebchaw uas ncaj qha mus rau qhov chaw nquag ntawm receptors. Allosteric modulation yog hais txog cov txheej txheem nyob rau hauv uas ib tug compound khi rau ib qho chaw sib txawv ntawm ib tug receptor, yog li cuam tshuam receptor conformation thiab kev ua ub no.

Tsis tas li ntawd, AF710B muaj cov qauv tshuaj me me uas tau hais tseg thiab tuaj yeem ua cov ntaub ntawv siv hauv receptor-txoj kev tshawb fawb los tshawb txog cov haujlwm receptor, kev cuam tshuam ntawm molecular, thiab cov txheej txheem biochemical muaj feem xyuam.

Khoom npe:AF710B hmoov
CAS: 1235733-73-9
MF:C20H27N3 OS
MW: 357.51
Lub neej txee:2 xyoo

 

Dab tsi ua rau AF710B txawv?

Qhov txawv ntawm AF710B thiab ntau cov tshuaj neuroactive tshuaj yog tias nws muaj ob txoj hauv kev ua haujlwm: M1 muscarinic receptors thiab sigma-1 receptors.

M1 receptor activation yog txuam nrog cholinergic signaling, thaum sigma-1 receptors koom nrog ntau yam txheej txheem intracellular, suav nrog calcium tshuav, cellular stress responses, thiab synaptic- ntsig txog cov haujlwm. Vim nws txoj haujlwm ntawm ob lub tshuab receptor sib txawv, AF710B tuaj yeem siv los kawm txog kev sib txuas ntawm cov kev taw qhia sib txawv. Lub hom phiaj ntawm ob lub hom phiaj no txawv nws ntawm cov tebchaw uas tsim los ua rau tib txoj hauv kev lom neeg.

Tam sim no, AF710B kuj tau siv rau hauv cov kev tshawb fawb ntsig txog kev paub txog kev ua haujlwm thiab lub paj hlwb hloov pauv. Piv txwv li, cov kev tshawb fawb muaj feem xyuam tau tshawb nrhiav nws cov teebmeem ntawm cov cim synaptic, amyloid-txoj kev cuam tshuam, thiab kev paub txog kev ua haujlwm. Txawm li cas los xij, nws cov teebmeem tshwj xeeb tseem xav tau kev tshawb fawb ntxiv thiab kev siv tau.

 

Muaj peev xwm siv AF710B Powder

AF710B hmoov tuaj yeem siv rau hauv ntau qhov chaw tshawb fawb ntsig txog molecular biology thiab neuroscience.

1. Kev Tshawb Fawb Txog Neuroscience

AF710B tuaj yeem siv los ua ib qho kev tshawb fawb los tshawb txog M1 muscarinic receptors, sigma-1 receptors, thiab lwm yam neuronal signaling pathways. Nws tuaj yeem pab kawm txog kev ua haujlwm receptor, kev sib txuas lus synaptic, thiab cov txheej txheem neuronal.

2. Nootropics-Txoj Kev Tshawb Fawb

Vim nws cov kev cuam tshuam nrog receptors cuam tshuam nrog lub paj hlwb teeb liab, AF710B tuaj yeem siv rau hauv kev tshawb fawb ntawm cov tebchaw cuam tshuam nrog kev paub txog kev ua haujlwm. Nws tuaj yeem ua ib qho chaw siv rau kev tshawb nrhiav cov txheej txheem molecular ntsig txog kev nco, kev kawm, thiab kev ua haujlwm neuronal.

3. Kev Tshawb Fawb Tshuaj thiab Tshuaj

Raws li cov tshuaj molecule me me, AF710B tuaj yeem siv rau hauv kev tshuaj ntsuam xyuas sib xyaw, kev tshawb fawb txog kev sib cuam tshuam ntawm molecular, thiab kev tshawb fawb uas muaj cov receptor- cov phiaj xwm sib txuas.

 

Ntxiv rau Af710b, peb kuj tsim lwm cov qib siab -cov kws tshuaj APIs zoo.

Yog tias koj muaj lus nug lossis xav tau, thov hu rau peb ntawm:sales01@pharmachemm.com

 

Cov ntaub ntawv siv thiab txhawb nqa

[1] Fisher A, Bezprozvanny I, Wu L, Ryskamp DA, Bar-Ner N, Natan N, Brandeis R, Elkon H, Nahum V, Gershonov E, LaFerla FM, Medeiros R. (2016). AF710B, Novel M1 / ​​σ1 Agonist nrog Kev Ua Haujlwm Zoo hauv Tsiaj Qauv ntawm Alzheimer's Disease. Neurodegener Dis.

[2] Hélène Hall, Maria Florencia Iulita, Palma Gubert, Lisi Flores Aguilar, Adriana Ducatenzeiler, Abraham Fisher, Augusto Claudio Cuello. (2018). AF710B, ib qho M1/sigma-1 receptor agonist nrog ntev -hloov kho cov kab mob nyob rau hauv ib tug transgenic nas qauv ntawm Alzheimer's kab mob.Alzheimer's & Dementia

Tsis lees paub:

Cov ntaub ntawv ntawm lub vev xaib no yog rau kev sib txuas lus thiab kev kawm nkaus xwb thiab tsis yog lus qhia kho mob. Nws yuav tsum tsis txhob siv rau kev kuaj mob lossis kho txhua yam mob.