Glutathione yog dab tsi?

1. Glutathione yog dab tsi?

 

Glutathioneyog ib qho tripeptide tsim los ntawm glutamic acid, cysteine ​​​​thiab glycine, muaj ib pab pawg neeg thiol, uas muaj cov tshuaj tua kab mob antioxidant thiab kev sib xyaw ua ke detoxification. Cov pab pawg thiol ntawm cysteine ​​​​yog cov pab pawg nquag ntawm glutathione (yog li glutathione feem ntau hu ua G-SH), uas yooj yim los ua ke nrog qee yam tshuaj (xws li paracetamol), co toxins (xws li dawb radicals, iodoacetic acid, mustard. roj, cov hlau hnyav xws li txhuas, mercury, arsenic, thiab lwm yam), thiab muaj kev sib xyaw ua ke detoxification. Yog li, glutathione (tshwj xeeb tshaj yog glutathione hauv daim siab hlwb) tuaj yeem koom nrog hauv biotransformation, yog li hloov cov co toxins hauv lub cev mus rau hauv cov khoom tsis zoo thiab tshem tawm ntawm lub cev. Glutathione tseem tuaj yeem pab tswj kev ua haujlwm ntawm lub cev tsis muaj zog.

 

Glutathioneyog dav nyob rau hauv cov tsiaj thiab nroj tsuag thiab plays lub luag hauj lwm tseem ceeb nyob rau hauv lub cev. Cov ntsiab lus nyob rau hauv baker cov poov xab, hom qoob mog thiab tsiaj lub siab yog siab heev, ncav cuag {{0}} mg/100g, nyob rau hauv tib neeg cov ntshav nws muaj 26-34 mg/100g, nyob rau hauv nqaij qaib cov ntshav nws muaj {{ 4}} mg/100g, hauv cov ntshav npua nws muaj 10-15 mg/100g, nyob rau hauv txiv lws suav, pineapples thiab dib nws kuj muaj cov ntsiab lus siab (12-33 mg/100g), thaum nyob rau hauv qos yaj ywm qab zib, mung taum sprouts, dos thiab nceb nws muaj cov ntsiab lus tsawg (0.06-0.7 mg/100g).

 

Glutathionemuaj ob hom: txo (G-SH) thiab oxidized (GSSG). Nyob rau hauv physiological tej yam kev mob, txo glutathione account rau feem coob. Glutathione reductase catalyzes interconversion ntawm ob daim ntawv. Lub coenzyme ntawm no enzyme yog NADPH muab los ntawm phosphate qab zib bypass metabolism.

 

2. Lub cev muaj zog ntawm Glutathione

 

Cov dawb radicals ntau dhau uas tsim los ntawm lub cev cov metabolism tuaj yeem ua rau cov kab mob lom neeg tsis zoo, cuam tshuam macromolecules, ua kom lub cev laus zuj zus, thiab ua rau cov qog nqaij hlav lossis atherosclerosis. Glutathione ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob biochemical hauv tib neeg lub cev thiab muaj ntau yam haujlwm ntawm lub cev. Nws lub ntsiab physiological muaj nuj nqi yog tshem tawm dawb radicals nyob rau hauv tib neeg lub cev. Raws li ib qho tseem ceeb antioxidant hauv lub cev, nws tiv thaiv cov pab pawg sulfhydryl hauv ntau cov proteins thiab enzymes. Cov qauv ntawm GSH muaj ib qho active sulfhydryl pawg -SH, uas yog yooj yim oxidized thiab dehydrogenated. Cov qauv tshwj xeeb no ua rau nws lub ntsiab dawb radical scavenger hauv lub cev.

 

Piv txwv li, thaum me me ntawm H2O2 tsim nyob rau hauv lub cell, GSH txo H2O2 rau H2O nyob rau hauv qhov kev txiav txim ntawm glutathione peroxidase, thiab nws tus kheej yog oxidized rau GSSG. GSSG raug txo rau GSH los ntawm glutathione reductase nyob rau hauv daim siab thiab cov qe ntshav liab, kom cov dawb radical tshem tawm cov tshuaj tiv thaiv hauv lub cev tuaj yeem txuas ntxiv mus.

 

Glutathionetuaj yeem tsis tsuas yog tshem tawm cov dawb radicals hauv tib neeg lub cev, tab sis kuj txhim kho tib neeg kev tiv thaiv. Glutathione tswj kev noj qab haus huv thiab tiv thaiv kev laus. Nws tseem tuaj yeem tiv thaiv hemoglobin los ntawm oxidation los ntawm hydrogen peroxide, dawb radicals, thiab lwm yam, kom nws tuaj yeem ua haujlwm txuas ntxiv mus rau kev thauj cov pa oxygen. Nyob rau hauv qhov kev txiav txim ntawm oxidants xws li hydrogen peroxide, divalent hlau nyob rau hauv ib co hemoglobin nyob rau hauv cov ntshav liab yog oxidized rau trivalent hlau, uas converts hemoglobin rau hauv methemoglobin, yog li poob nws oxygen-carrying peev.

 

Txo glutathione tuaj yeem ncaj qha ua ke nrog oxidants xws li hydrogen peroxide los tsim dej thiab oxidized glutathione, thiab tuaj yeem txo methemoglobin rau hemoglobin. Cov ntsiab lus ntawm glutathione nyob rau hauv tib neeg cov qe ntshav liab yog siab heev, uas yog ib qho tseem ceeb heev rau kev tiv thaiv cov sulfhydryl pawg ntawm cov proteins nyob rau hauv cov ntshav liab daim nyias nyias nyob rau hauv lub xeev txo thiab tiv thaiv hemolysis.

Glutathione tiv thaiv pab pawg -SH hauv cov enzyme molecule, uas yog qhov tsim nyog rau kev ua haujlwm ntawm cov enzyme, thiab tuaj yeem rov ua haujlwm ntawm pawg -SH hauv cov enzyme uas puas lawm, kom cov enzyme tuaj yeem rov ua haujlwm. Glutathione tuaj yeem tiv thaiv daim siab rog los ntawm ethanol puas rau daim siab.

 

Glutathionemuaj kev tiv thaiv zoo rau cov tsos mob xws li leukopenia tshwm sim los ntawm hluav taws xob thiab tshuaj radioactive. Glutathione tuaj yeem ua ke nrog cov tshuaj lom neeg, cov hlau hnyav ions lossis cov carcinogens uas nkag mus rau tib neeg lub cev thiab txhawb nqa lawv cov kev tawm hauv lub cev, ua si lub luag haujlwm tsis zoo thiab tshem tawm cov co toxins.

 

3. Kev thov dav ntawm Glutathione

 

Glutathione muaj broad-spectrum detoxification nyhuv. Nws tuaj yeem siv tsis tau tsuas yog hauv cov tshuaj, tab sis kuj yog cov khoom siv hauv cov khoom noj khoom haus. Nws yog dav siv nyob rau hauv cov khoom noj xws li ncua kev laus, txhim khu kev tiv thaiv, thiab tiv thaiv qog.

 

Cov tshuaj kho mob

GlutathioneCov tshuaj tau raug tsim tawm thiab siv dav hauv kev kho mob. Ntxiv nrog rau kev siv nws cov thiol pawg los chelate cov hlau hnyav, fluoride, mustard gas thiab lwm yam co toxins, nws kuj yog siv rau hauv kab mob siab, kab mob hemolytic, keratitis, cataracts thiab cov kab mob retinal raws li kev kho mob los yog tshuaj pab kho mob. Nyob rau xyoo tas los no, cov kws tshawb fawb sab hnub poob, tshwj xeeb tshaj yog cov kws tshawb fawb Nyij Pooj, tau tshawb pom tias glutathione muaj lub luag haujlwm ntawm inhibiting HIV.

 

Cov kev tshawb fawb tshiab tseem qhia tau tias GSH tuaj yeem kho qhov tsis sib xws ntawm acetylcholine thiab cholinesterase, ua lub luag haujlwm tiv thaiv kev ua xua, tiv thaiv kev laus ntawm daim tawv nqaij thiab pigmentation, txo qhov tsim ntawm melanin, txhim kho daim tawv nqaij antioxidant muaj peev xwm thiab ua rau daim tawv nqaij ci. Tsis tas li ntawd, GSH kuj muaj txiaj ntsig zoo hauv kev kho mob pob txha thiab txhim kho kev sib deev.

 

Ua ke nrog vitamin C

Tsis tas li ntawd, vitamin C kuj yog ib qho tseem ceeb antioxidant hauv lub cev. Txij li thaum vitamin C tuaj yeem thim rov qab hydrogenated lossis dehydrogenated, vitamin C plays lub luag haujlwm tseem ceeb hauv ntau cov tshuaj tiv thaiv redox hauv lub cev. Piv txwv li, cov active pab pawg neeg ntawm ntau enzymes yog sulfhydryl (-SH), thiab vitamin C muaj peev xwm tswj tau -SH nyob rau hauv ib tug txo nyob rau hauv lub xeev kom tswj cov kev ua ntawm lub enzyme; vitamin C tuaj yeem hloov oxidized glutathione rau hauv txo glutathione (GSH), txo hydrogen peroxide (H2O2) uas tsim los ntawm lub cev metabolism; vitamin C kuj tuaj yeem tiv thaiv vitamin A, E thiab qee cov vitamins B los ntawm oxidation. Yog li ntawd, thaum siv glutathione, siv nws ua ke nrog vitamin C tuaj yeem txhim kho nws cov txiaj ntsig.

 

4. Cov Ntsiab Cai Tseem Ceeb Rau Kev Txiav Txim Cov Ntsiab Lus Glutathione

 

GSH yog cov tshuaj antioxidant thiol tseem ceeb tshaj plaws hauv cov hlwb thiab ua lub luag haujlwm tseem ceeb hauv antioxidant, protein thiol tiv thaiv thiab amino acid transmembrane thauj. Qhov piv ntawm kev txo qis rau oxidized (GSH / GSSG) yog lub ntsiab dynamic qhia ntawm cellular redox xwm txheej. Yog li ntawd, ntsuas qhov intracellular GSH thiab GSSG cov ntsiab lus thiab GSH / GSSG piv tuaj yeem cuam tshuam txog lub xeev redox ntawm cov hlwb thiab kuj yog ib qho ntawm cov cim tseem ceeb ntawm glutathione redox voj voog.

 

GlutathioneTxo daim ntawv (G-SH) ntsuas txoj cai:

Glutathionergic thiab 5,5'dithio-bis-(2-nitrobenzoic acid) (5,5'
-dithiobis-2-nitrobenoicacid (DTNB) reacts los tsim 2-nitro-5-mercaptobenzoic acid thiab glutathione disulfide (GSSG). 2-Nitro-5-mercaptobenzoic acid yog cov khoom daj nrog lub teeb pom kev siab tshaj plaws ntawm lub wavelength ntawm 412nm, thiab nws absorbance yog proportional rau GSH cov ntsiab lus.

 

Lub hauv paus ntsiab lus ntawm kev txiav txim siab ntawm oxidized glutathione (GSSG):

Oxidized glutathione (GSSG) yog oxidized daim ntawv ntawm glutathione (GSH), tseem hu ua disulfide glutathione, uas yog tsim los ntawm oxidation ntawm ob molecules ntawm glutathione. GSSG yuav raug txo rau GSH los ntawm glutathione reductase, yog li feem ntau ntawm nws muaj nyob hauv lub cev hauv daim ntawv txo.

 

Tus thawj txo glutathione hauv cov qauv yog inhibited los ntawm 2-vinylpyridine, thiab ces glutathione reductase yog siv los txo GSSG rau GSH. Glutathione tuaj yeem ua haujlwm nrog 5,5'-dithiobis-2-nitrobenoic acid (DTNB) los tsim 2-nitro-5-mercaptobenzoic acid. 2-Nitro-5-mercaptobenzoic acid muaj cov yam ntxwv ntawm qhov siab tshaj plaws lub teeb nqus ntawm lub wavelength ntawm 412nm, uas yog siv los txiav txim cov ntsiab lus ntawm oxidized glutathione.

 

Leej Twg Yog Tus BPuas yog Glutathione Supplier?

Yog tias koj tab tom nrhiav rau ib lub khw muag khoom noj rauGlutathione, ces qhov zoo tshaj plaws rau kev yuav khoom ntau yog Jinan Jianfeng Tshuaj. Peb lub tuam txhab muaj ntau yam khoom siv tshuaj pleev ib ce.

cov khoom ntawm tus nqi tsim nyog. Nws kuj tseem yog cov khoom siv raw khoom uas ua raws li GMP, ISO cov qauv thiab tseem yog cov khoom lag luam paub zoo.

 

Yuav koom tes nrog peb li cas?

 

-- Tiv tauj peb ntawm Email.

 

--Cia peb cov lus hais txog cov khoom koj xav tau.

 

--Kev piav qhia ntawm qhov kev txiav txim kom muaj nuj nqis.

 

--Thov qhia rau peb paub koj qhov chaw nyob shipping.

 

--Tus thawj tswj kev muag khoom muab nqe lus rau koj thiab xa daim ntawv cog lus rau koj.

 

--Kev xa khoom tib hnub tom qab them nyiaj.