Kev Tshawb Nrhiav Kev Txhim Kho Ntawm Polypeptide Cov Tshuaj Rau Kev Kho Mob Ntawm Cov Kab Mob Autoimmune

Xyoo tsis ntev los no, cov kev tshawb fawb tau pom tias peptide tshuaj muaj hom phiaj rau tshwj xeeb epitopes tuaj yeem kho kab mob autoimmune, uas tuaj yeem zam qhov tsis muaj kev tiv thaiv kab mob ntawm cov tshuaj ib txwm muaj, thiab tau qhia tias muaj kev kho mob zoo hauv cov tsiaj qauv ntawm cov kab mob autoimmune thiab kev sim tshuaj. Hais txog qhov chaw ntawm cov neeg sib tw peptides uas inhibit autoimmune teb thiab lawv cov kev ua ntawm kev ua, tsab xov xwm no tshuaj xyuas qhov kev tshawb nrhiav kev txhim kho thiab tiam sis cov tshuaj peptide rau kev kho cov kab mob autoimmune hauv xyoo tsis ntev los no, thiab qhia qhov kev tshawb xav rau kev nkag siab thiab tob. nkag siab txog lub cev tsis haum ntawm lub cev tiv thaiv kab mob autoimmune thiab tshawb cov qauv tshiab. nyob rau hauv raws li.

Qhia lub ntsiab kev tshawb fawb tseem ceeb ntawm pharmacogenomics nyob hauv tsev thiab txawv teb chaws, xws li methotrexate, cyclophosphamide, azathioprine, qog necrosis factor alpha antagonist, thiab ntxiv rau cov kab mob autoimmune, suav nrog kev tshuaj tua kab mob caj ces thiab tshuaj nyob rau hauv lub luag hauj lwm ntawm cov tshuaj tiv thaiv lossis hom phiaj polymorphism kwv yees kev ua tau zoo ntawm tshuaj thiab qhov tshwm sim tsis zoo.

Polypeptide thiab cov tshuaj protein muaj cov kev kho kom zoo rau kev mob qog nqaij hlav thiab mob autoimmune. Tam sim no, kev npaj cov kev lag luam peptide feem ntau yog kev txhaj tshuaj, thiab kev txhaj tshuaj ntau zaus ua rau muaj mob loj rau cov neeg mob. Microsphere npaj tau qeeb-tso cov tshuaj ntau xyoo nyob rau xyoo tas los Kev tshawb fawb hotspots, raws li kev xav tau hauv kev kho mob, ntau cov tshuaj tau tshawb rau microsphere npaj, xws li tshuaj tiv thaiv qog noj ntshav thiab tshuaj peptide protein. Cov ntawv sau no tshawb xyuas cov kev tshawb nrhiav tam sim no thiab kev npaj cov protein thiab peptide tshuaj microsphere npaj. Taw qhia.

Lub luag haujlwm ntawm peptide thiab cov tshuaj protein nyob hauv kev kho tib neeg cov kab mob tau dhau los ua qhov tseem ceeb dua. Kev txhim kho ntawm cov tshuaj microsphere xa mus rau cov peptide thiab cov tshuaj protein tuaj yeem tiv thaiv kev puas tsuaj sai ntawm cov tshuaj hauv lub cev thiab ua kom zoo xa cov tshuaj mus rau qhov sib thooj ntawm tib neeg lub cev. Qhov no yog kev txhim kho peptide thiab tshuaj protein. Thiab siv yog cov ntsiab lus tshwj xeeb. Ntawm nimno, txoj kev siv ntau hauv kev npaj ntawm microspheres suav nrog txheej txheem ua kua kom qhuav, tshuaj tsuag kom qhuav txoj hau kev, theem sib cais txoj kev thiab hom kev sib txuam emulsification.