Inhibitor LOXO-292

Selpercatinib Inhibitor LOXO-292 cas 2152628-33-4 yog qhov ncauj thiab xaiv kev tshawb nrhiav tus neeg sawv cev tshiab uas raug tshuaj xyuas rau kev kho mob rau cov neeg mob qog nqaij hlav uas muaj kev hloov pauv hauv RET kinase hauv LIBRETTO-001 kev sim (NCT03157128).

Xa kev nug

Hauj lwm lawm

Khoom taw qhia：

CAS: 2152628-33-4

MF:C₂₉H₃₁N₇O₃

Lub cev nyhav: 525.6

Synoyms:LOXO292, Selpercatinib, LY3527723, CPD2206

Kev piav qhia:Selpercatinib Inhibitor LOXO-292 cas 2152628-33-4 yog qhov ncauj thiab xaiv kev tshawb nrhiav tus neeg sawv cev tshiab uas raug tshuaj xyuas rau kev kho mob rau cov neeg mob qog nqaij hlav uas muaj kev hloov pauv hauv RET kinase hauv LIBRETTO-001 kev sim (NCT03157128).

Daim ntawv thov:Kho cov qog ua haujlwm siab, histiocytic tsis zoo uas tau ua kom RET gene hloov mus. Selpercatinib thaiv txoj kev loj hlob ntawm cov qog nqaij hlav cancer uas muaj kev hloov pauv tshwj xeeb hauv txoj kev qhia tseem ceeb (hu ua RET pathway) thiab yuav txo qhov qog loj tuaj.

Lwm cov npe tshuaj:SELPERCATINIB, Selpercatinib (LOXO-292)

Daim ntawv pov thawj kev tshuaj xyuas

NTU	TXHEEM	TSHAJ
Tsos	Dawb txhaws kom dawb-hmoov	Hmoov dawb dawb
LC / MS	Kev sib xyaw nrog cov qauv	Ntxuas Sib
NMR	Kev sib xyaw nrog cov qauv	Ntxuas Sib
Poob rau kom qhuav	≤0.5%	0.21%
Qhov tshuaj sib thooj los ntawm HPLC	Ib leeg tsis muaj peev xwm ≤ 0.5% Tag nrho impurities≤1.0%	0.3% 0.42%
Ntsuas	Xam los ntawm cov hauv paus tsis muaj zog, 98.0% ~ 102.0%	99.3%

Ntim

Cov khoom me me Tus Qauv LOXO-292 cas 2152628-33-4 zoo li 1kg yuav tau ntim rau hauv ob lub hnab yas ntim khoom thiab ib lub hnab ntawv ci, thiab ntau qhov loj Inhibitor LOXO-292 cas 2152628-33-4 zoo li 25kg yuav raug kaw rau hauv fiber ntau nruas.

Lub chaw soj nstuam thiab chaw ua haujlwm