Olivetolic Acid

Olivetolic acid yog dab tsi?

Olivetolic acid (OA) yog polyketide muab tau los ntawm tetraketide precursor, ib qho tseem ceeb nruab nrab ntawm biosynthesis ntawm ntau yam metabolites theem nrab hauv cov nroj tsuag. Nws yog cov qauv zoo ib yam li lwm cov polyketides, xws li cov khoom lag luam paub zoo polyketide synthase (PKS), lovastatin, uas yog siv los ua cov tshuaj txo cov roj cholesterol. Tsis ntev los no, tau muaj kev txaus siab ntxiv rau cov kev siv peev xwm ntawm OA vim nws cov haujlwm lom neeg ntau yam. Hauv tsab xov xwm no, peb yuav tham txog cov kev tshawb fawb tam sim no ntawm daim ntawv thov OA, uas suav nrog tshuaj tua kab mob, tshuaj tiv thaiv kab mob, tiv thaiv qog, neuroprotective, thiab antioxidant zog.

Kev siv ntawm Olivetolic acid:

1. Kev tiv thaiv kab mob

OA tau pom tias muaj cov tshuaj tiv thaiv kab mob tseem ceeb tiv thaiv ntau yam kab mob thiab fungi. Qhov no tau raug ntaus nqi rau nws lub peev xwm los tiv thaiv kev loj hlob ntawm cov kab mob no los ntawm kev cuam tshuam lawv cov cellular membranes. Ib txoj kev tshawb fawb los ntawm Chaudhari et al. (2012) tau pom tias OA muab rho tawm los ntawm Cannabis sativa pom muaj zog tiv thaiv kab mob tiv thaiv ntau yam kab mob, suav nrog S. aureus, P. aeruginosa, thiab E. coli. Lawv kuj pom tias OA muaj kev sib koom ua ke thaum siv nrog cov tshuaj tua kab mob, qhia tias nws tuaj yeem yog kev kho mob ntxiv rau cov tshuaj tua kab mob tiv thaiv kab mob.

2. Kev tiv thaiv kab mob

OA kuj tau pom tias muaj cov tshuaj tiv thaiv kab mob. Nws tau pom tias inhibit zus tau tej cov pro-inflammatory cytokines thiab chemokines, yog li ntawd txo o nyob rau hauv ntau yam ntaub so ntswg. Kev tshawb fawb los ntawm Wu et al. (2018) tshawb xyuas cov tshuaj tiv thaiv kab mob ntawm OA ntawm lipopolysaccharide (LPS)-induced RAW264.7 hlwb. Lawv pom tias kev kho OA txo qis kev tsim cov cytokines xws li TNF- , IL-1 , thiab IL-6. Qhov no qhia tias OA tuaj yeem siv los ua tus neeg sawv cev kho mob rau cov kab mob inflammatory.

3. Antitumor Activity

OA tau pom tias muaj cov tshuaj tiv thaiv kab mob, ua rau nws muaj kev vam meej rau kev kho mob qog noj ntshav. Hauv kev tshawb fawb los ntawm Hsia et al. (2017), lawv pom tias OA inhibited qhov kev loj hlob ntawm ntau cov qog nqaij hlav cancer, nrog rau lub mis, lub ntsws, txoj hnyuv, thiab cov qog nqaij hlav cancer prostate. Lawv kuj pom tias OA ua rau apoptosis hauv cov qog nqaij hlav cancer los ntawm kev ua kom cov caspase-3 thiab nce kev qhia ntawm Bax. Qhov no qhia tau tias OA tuaj yeem siv los ua tus kws khomob kws khomob rau ntau hom kabmob kheesxaws.

4. Kev ua haujlwm Neuroprotective

OA kuj tau pom tias muaj cov khoom tiv thaiv neuroprotective, ua rau nws muaj peev xwm kho tau tus kab mob neurodegenerative. Nws tau pom tias tiv thaiv neurons los ntawm oxidative kev nyuaj siab thiab inhibit neuroinflamation. Hauv kev tshawb fawb los ntawm Gao et al. (2018), lawv pom tias OA tiv thaiv PC12 hlwb los ntawm oxidative kev nyuaj siab los ntawm kev txo cov kev tsim cov pa reactive oxygen hom (ROS) thiab ua rau cov kev ua ntawm endogenous antioxidant enzymes. Lawv kuj pom tias OA inhibited neuroinflamation los ntawm suppressing cov kev qhia ntawm pro-inflammatory cytokines. Qhov no qhia tias OA tuaj yeem siv los ua tus neeg sawv cev kho mob zoo rau kev kho cov kab mob neurodegenerative.

5. Antioxidant Kev Ua Haujlwm

OA tau pom tias muaj cov tshuaj antioxidant muaj zog. Nws tau pom tias yuav tshem tawm cov dawb radicals thiab txo oxidative kev nyuaj siab hauv hlwb. Hauv kev tshawb fawb los ntawm Lin et al. (2017), lawv pom tias OA muaj zog dawb radical scavenging kev ua si thiab inhibited lipid peroxidation hauv vitro. Lawv kuj pom tias OA tiv thaiv cov hlwb los ntawm hydrogen peroxide-induced oxidative kev nyuaj siab los ntawm kev ua kom cov enzymes antioxidant. Qhov no qhia tau tias OA tuaj yeem siv los ua tus neeg sawv cev kho mob zoo rau kev kho mob ntawm cov kab mob oxidative kev nyuaj siab.

6. Cov lus xaus

Hauv kev xaus, cov kev siv tau ntawm OA muaj ntau thiab ntau yam. Nws cov tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, neuroprotective, thiab antioxidant zog ua rau nws muaj kev vam meej rau kev txhim kho ntawm ntau yam tshuaj kho. Txawm li cas los xij, cov kev tshawb fawb ntxiv yuav tsum tau ua kom tiav nws cov txheej txheem ntawm kev ua haujlwm thiab ntsuas nws txoj kev nyab xeeb thiab kev ua tau zoo hauv vivo.

 

 

Vim li cas thiaj xaiv peb?

Jinan Jianfeng Chemical Co., Ltd. yog ib lub tuam txhab headquartered nyob rau hauv Jinan, Suav teb, uas yog tshwj xeeb nyob rau hauv txoj kev loj hlob, ntau lawm thiab muag khoom ntawm cov tshuaj intermediates, APIs (active tshuaj cov khoom xyaw), tshuaj pleev ib ce raw khoom thiab zoo tshuaj. Lub tuam txhab muaj lub xeev-of-the-art manufacturing chaw thiab R & D chaw nruab nrog advanced technology thiab khoom siv los xyuas kom meej cov khoom zoo. Jinan Jianfeng Chemical Co., Ltd. tau tsim lub koob npe nrov hauv kev lag luam nrog nws txoj kev mob siab rau kev ua tau zoo, kev tsim kho tshiab thiab kev pabcuam rau cov neeg siv khoom. Lub tuam txhab tau cog lus los muab cov neeg siv khoom muaj kev nyab xeeb thiab cov khoom siv tau zoo uas ua tau raws li cov qauv zoo tshaj plaws thiab ua raws.

Jinan Jianfeng Chemical tshwj xeeb hauv kev muab cov khoom siv raw rau cov tshuaj pleev ib ce, cov khoom siv rau cov tshuaj tua kab mob, cov khoom siv rau cov tshuaj tiv thaiv kev nyuaj siab, cov khoom siv raw rau cov tshuaj nootropic, thiab ntau yam tshuaj intermediates. Peb txuas ntxiv tshawb fawb thiab tsim kho tshiab, thiab muab peb cov neeg siv khoom zoo thiab pheej yig cov khoom lag luam thiab cov kev pabcuam zoo. Yog tias koj xav tau, thov koj xav xa cov lus nug rausales01@pharchemm.com.

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