Spermidine ntxiv

Spermidine hmoov, lub ntuj polyamine, yog tus cwj pwm los ntawm nws cov daj daj crystalline los yog hmoov, uas muaj protonated guanidine pawg, ob pawg guanidine, thiab ib pawg beta-alanine. Cov dej-soluble compound no, nrog cov ntxhiab tsw qab, yooj yim ionizes rau hauv cov khoom muaj txiaj ntsig zoo, ua rau nws tus qauv tshuaj rau kev ua haujlwm hydrolase.

Tam sim no nyob rau hauv txhua lub cell ntawm lub cev, kwv yees li ib feem peb ntawm Spermidine yog tsim endogenously, thaum ob feem peb yog absorbed los ntawm cov khoom noj txhua hnub, tshwj xeeb tshaj yog los ntawm cov kab mob plab. Ntau yam khoom noj muaj txiaj ntsig rau qib Spermidine, thiab ntawm no yog qee qhov piv txwv:

Txiv Hmab Txiv Ntoo: Txiv nkhaus taw sawv nrog cov ntsiab lus siab tshaj plaws ntawm 3 mg / 100 g.

Nqaij thiab ntses: Nqaij nyuj hauv av muaj cov ntsiab lus siab tshaj plaws ntawm cov nqaij thiab ntses, ntawm 4 mg / 100 g.

Txiv ntseej thiab txiv hmab txiv ntoo qhuav: Hazelnuts coj pawg no nrog 2 mg / 100 g.

Zaub: Pob kws yog cov npe ntawm cov zaub, nrog rau cov ntsiab lus ntawm 3 mg / 100 g.

Lwm qhov chaw:

Cov kab mob: 24.3 mg / 100 g
Cheddar cheese: 19 mg / 100 g
Peas: 6-14 mg / 100 g
Taum liab: 19 mg / 100 g
Broccoli thiab cauliflower: 2-10 mg/100 g
Parisian Shiitake Mushrooms: 9 mg / 100 g
Yog ': 3 mg/100 g
Celery thiab melon: 2 mg / 100 g
Whole wheat bread: 2 mg/100 g
 

Spermidine VS NMN

Spermidine thiab NMN (Nicotinamide Mononucleotide) yog ob qho tib si nrov cov khoom xyaw cuam tshuam nrog kev tiv thaiv kev laus thiab kev ua neej ntev, txhua qhov sib txawv ntawm kev ua haujlwm. Txawm hais tias ob qho tib si cov khoom yog soluble thiab ruaj khov hauv dej, lawv txoj hauv kev los txhawb lub neej ntev sib txawv.

Spermidine, paub txij li nws tshawb pom los ntawm Dutch tus kws tshawb fawb Leeuwenhoek hauv xyoo 1678, tau kawm ntau yam, nrog rau kev tshaj tawm hauv cov ntawv xov xwm muaj koob npe zoo li "Nature" thiab "Science." Spermidine's anti-aging teebmeem feem ntau suav nrog:

Kev Tshaj Tawm Autophagy: Spermidine ua lub luag haujlwm tseem ceeb hauv kev nce autophagy, cov txheej txheem ntuj tshem tawm cov khoom pov tseg ntawm tes, ua kom huv ntawm lub cell ib puag ncig, thiab nquag pab txhawb kom qeeb cov txheej txheem kev laus.

Mitophagy Promotion: Spermidine kuj txhawb mitophagy, txhawb kev noj qab haus huv ntawm mitochondria, lub cell lub zog tsim.

mTOR Inhibition: Spermidine inhibits mTOR (mechanistic lub hom phiaj ntawm rapamycin), tiv thaiv kev ua haujlwm ntau dhau uas tuaj yeem ua rau mob qog noj ntshav thiab ua rau kev laus.

AMPK Kev Ua Haujlwm: Spermidine activates AMPK (adenosine monophosphate-activated protein kinase), ib txoj hauv kev tseem ceeb rau kev noj qab haus huv uas pab txo qhov mob thiab txhawb kev rog rog. Hauv kev sim nematode, ntxiv Spermidine los qhib AMPK tau pom tias yuav txuas ntxiv lub neej los ntawm 15%.

Ntawm qhov tod tes, NMN hmoov ua tiav los tiv thaiv kev laus los ntawm kev nce qib ntawm NAD + (nicotinamide adenine dinucleotide) hauv lub cev.

Nyob nruab nrab ntawm ob, Spermidine supplementation yog suav tias yog ib txoj hauv kev zoo vim nws cov txiaj ntsig los tiv thaiv kev laus ntau. Los ntawm kev txhawb nqa autophagy, inhibiting mTOR, ua kom AMPK, thiab txhawb nqa kev noj qab haus huv ntawm mitochondrial, Spermidine muab cov tswv yim zoo rau kev ua kom qeeb ntawm kev laus.

Spermidine, tau qhuas tias yog tus choj muaj peev xwm los tiv thaiv kev puas siab puas ntsws, tau txais kev saib xyuas rau nws cov txiaj ntsig kev noj qab haus huv ntau yam, dhau ntawm NMN uas yog lwm txoj hauv kev zoo tshaj. Ib txoj kev tshawb fawb los ntawm cov kws tshawb fawb ntawm Tsoom Fwv Teb Chaws University of Santa Maria hauv Brazil, luam tawm nyob rau hauv "European Journal of Pharmacology," delved rau hauv Spermidine qhov cuam tshuam rau kev nco persistence hauv nas. Siv cov cuab yeej tiv thaiv kev ntshai, nas tau raug cob qhia thiab tom qab ntawd txhaj tshuaj saline lossis Spermidine 12 teev tom qab. Cov txiaj ntsig tau pom tias Spermidine, tshwj xeeb tshaj yog nyob rau ntawm koob tshuaj 10mg / kg thiab 30mg / kg, txhim kho kev ntshai nco tau zoo nyob rau hnub thib 2 thiab 7 tom qab kev cob qhia. Ntxiv mus, Spermidine tau qhia nws lub peev xwm los txo cov teebmeem neurotoxic ntawm acaine ntawm kev nco, qhib txoj hauv kev tshiab rau kev tshawb nrhiav ntxiv ntawm nws cov kev txawj ntse.

 

Spermidine tsis nres ntawm cov txiaj ntsig kev paub; nws tau ua pov thawj tias nws yog ib qho tseem ceeb hauv kev tiv thaiv kab mob plawv. Kev tshawb fawb luam tawm hauv Atherosclerosis hauv xyoo 2016 tau lees paub Spermidine lub luag haujlwm hauv kev txo qis lipid tsub zuj zuj hauv atherosclerotic plaques. Lwm txoj kev tshawb fawb hauv Nature Medicine tib lub xyoo tau nthuav tawm nws lub peev xwm los txo qis plawv hypertrophy, txhim kho diastolic muaj nuj nqi, thiab txuas ntxiv lub neej ntawm cov nas. Tib neeg cov kev tshawb fawb tau txhawb nqa qhov kev lees paub tias kev noj zaub mov Spermidine txhim kho ntshav siab thiab txo qhov tshwm sim ntawm cov kab mob plawv.

 

Hais txog cov kab mob metabolic, kev tshawb fawb hauv European Journal of Pathology hauv xyoo 2014 tau pom tias Spermidine supplementation txhim kho kev siv cov piam thaj thiab txo lub cev hnyav hauv cov nas rog rog. Xyoo 2017, Cell Death & Disease, ib phau ntawv xov xwm ntawm Xwm Txheej, luam tawm ib txoj kev tshawb fawb qhia txog Spermidine lub peev xwm los tiv thaiv qhov hnyav nce los ntawm kev noj zaub mov muaj calorie ntau thiab txo cov tsos mob ntsig txog kev rog.

 

Kev cog lus ntawm Spermidine txuas mus rau mob qog noj ntshav thiab. Ntau cov kev tshawb fawb qhia nws lub peev xwm los txo cov qog loj hlob hauv cov nas, xws li txo qis qhov tshwm sim ntawm cov qog pom ntawm daim tawv nqaij, ua kom qeeb ntawm cov qog nqaij hlav hauv plab, thiab txo qhov tshwm sim ntawm daim siab mob qog noj ntshav hauv cov nas uas muaj daim siab fibrosis. Tsis tas li ntawd, Spermidine tau pom muaj peev xwm los txhim kho cov qog nqaij hlav tiv thaiv kab mob.

Kev sim tshuaj rau cov neeg laus tau tsim kev nyab xeeb ntawm kev noj 1.2 mg / hnub ntawm Spermidine, thaum qhov ntau npaum li cas rau nws cov txiaj ntsig kev noj qab haus huv thiab kev tiv thaiv kev laus yog 1-10 mg / hnub. Txhawm rau kom pom kev zoo, nws raug nquahu kom noj Spermidine hauv 30 feeb tom qab noj mov. Cov ntaub ntawv pov thawj qhia tau hais tias Spermidine tuav cov lus cog tseg ua ntau yam thiab muaj zog sib txuas rau kev txhawb nqa tag nrho kev noj qab haus huv thiab kev ua neej ntev.

 

Spermidine tuaj yeem ua rau kev sib raug zoo ntawm tib neeg thiab kev dementia
Spermidine, tau qhuas tias yog tus choj muaj peev xwm los tiv thaiv kev puas siab puas ntsws, tau txais kev saib xyuas rau nws cov txiaj ntsig kev noj qab haus huv ntau yam, dhau ntawm NMN uas yog lwm txoj hauv kev zoo tshaj. Ib txoj kev tshawb fawb los ntawm cov kws tshawb fawb ntawm Tsoom Fwv Teb Chaws University of Santa Maria hauv Brazil, luam tawm nyob rau hauv "European Journal of Pharmacology," delved rau hauv Spermidine qhov cuam tshuam rau kev nco persistence hauv nas. Siv cov cuab yeej tiv thaiv kev ntshai, nas tau raug cob qhia thiab tom qab ntawd txhaj tshuaj saline lossis Spermidine 12 teev tom qab. Cov txiaj ntsig tau pom tias Spermidine, tshwj xeeb tshaj yog nyob rau ntawm koob tshuaj 10mg / kg thiab 30mg / kg, txhim kho kev ntshai nco tau zoo nyob rau hnub thib 2 thiab 7 tom qab kev cob qhia. Ntxiv mus, Spermidine tau qhia nws lub peev xwm los txo cov teebmeem neurotoxic ntawm acaine ntawm kev nco, qhib txoj hauv kev tshiab rau kev tshawb nrhiav ntxiv ntawm nws cov kev txawj ntse.

 

Kev tiv thaiv kab mob plawv
Spermidine tsis nres ntawm cov txiaj ntsig kev paub; nws tau ua pov thawj tias nws yog ib qho tseem ceeb hauv kev tiv thaiv kab mob plawv. Kev tshawb fawb luam tawm hauv Atherosclerosis hauv xyoo 2016 tau lees paub Spermidine lub luag haujlwm hauv kev txo qis lipid tsub zuj zuj hauv atherosclerotic plaques. Lwm txoj kev tshawb fawb hauv Nature Medicine tib lub xyoo tau nthuav tawm nws lub peev xwm los txo qis plawv hypertrophy, txhim kho diastolic muaj nuj nqi, thiab txuas ntxiv lub neej ntawm cov nas. Tib neeg cov kev tshawb fawb tau txhawb nqa qhov kev lees paub tias kev noj zaub mov Spermidine txhim kho ntshav siab thiab txo qhov tshwm sim ntawm cov kab mob plawv.

 

Ib txoj hauv kev los txhim kho cov kab mob metabolic
Hais txog cov kab mob metabolic, kev tshawb fawb hauv European Journal of Pathology hauv xyoo 2014 tau pom tias Spermidine supplementation txhim kho kev siv cov piam thaj thiab txo lub cev hnyav hauv cov nas rog rog. Xyoo 2017, Cell Death & Disease, ib phau ntawv xov xwm ntawm Xwm Txheej, luam tawm ib txoj kev tshawb fawb qhia txog Spermidine lub peev xwm los tiv thaiv qhov hnyav nce los ntawm kev noj zaub mov muaj calorie ntau thiab txo cov tsos mob ntsig txog kev rog.

 

Cia siab rau hauv kev sib ntaus tawm tsam mob qog noj ntshav
Kev cog lus ntawm Spermidine txuas mus rau mob qog noj ntshav thiab. Ntau cov kev tshawb fawb qhia nws lub peev xwm los txo cov qog loj hlob hauv cov nas, xws li txo qis qhov tshwm sim ntawm cov qog pom ntawm daim tawv nqaij, ua kom qeeb ntawm cov qog nqaij hlav hauv plab, thiab txo qhov tshwm sim ntawm daim siab mob qog noj ntshav hauv cov nas uas muaj daim siab fibrosis. Tsis tas li ntawd, Spermidine tau pom muaj peev xwm los txhim kho cov qog nqaij hlav tiv thaiv kab mob.

Kev sim tshuaj rau cov neeg laus tau tsim kev nyab xeeb ntawm kev noj 1.2 mg / hnub ntawm Spermidine, thaum qhov ntau npaum li cas rau nws cov txiaj ntsig kev noj qab haus huv thiab kev tiv thaiv kev laus yog 1-10 mg / hnub. Txhawm rau kom pom kev zoo, nws raug nquahu kom noj Spermidine hauv 30 feeb tom qab noj mov. Cov ntaub ntawv pov thawj qhia tau hais tias Spermidine tuav cov lus cog tseg ua ntau yam thiab muaj zog sib txuas rau kev txhawb nqa tag nrho kev noj qab haus huv thiab kev ua neej ntev.

 

Kuv tuaj yeem yuav spermidine hmoov nyob qhov twg?

Jinan Jianfeng Chemical Co., Ltd. yog koom nrog kev tsim kho, tsim khoom thiab muag khoom ntawm spermidine hmoov. Lub tuam txhab muaj cov chaw tsim khoom siab heev thiab R & D cov chaw nruab nrog cov cuab yeej siv siab heev thiab cov cuab yeej siv los xyuas kom meej cov khoom zoo.

Peb cov khoom yog semi-tiav raw cov ntaub ntawv thiab feem ntau yog muag rau cov tuam txhab uas muag muaj peev xwm ua. Cov khoom lag luam yog muag rau North America, Europe, South America, Australia thiab Middle East thiab lwm lub tebchaws. Cov khoom tsis yog cov khoom tiav thiab tsis pom zoo rau kev yuav khoom thiab siv tus kheej.

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